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SynKinase
R406
CHF 0.00
In stock
SYN-1121-M0011 mgCHF 142.00
SYN-1121-M0055 mgCHF 234.00
SYN-1121-M01010 mgCHF 355.00
SYN-1121-M05050 mgCHF 1'206.00
SYN-1121-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | R-406 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H23FN6O5 |
| MW | 470.5 |
| CAS | 841290-80-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Syk | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | NHHQJBCNYHBUSI-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3.
Product References
- R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation: S. Braselmann, et al.; J. Pharmacol. Exp. Ther. 319, 998 (2006)
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