GSK25

CHF 227.00
In stock
SYN-1124-M0011 mgCHF 227.00
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More Information
Product Details
Synonyms GSK-25
Product Type Chemical
Properties
Formula C24H16Cl2F2N6O
MW 513.3
CAS 874119-56-9
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: RSK1 - p70S6K | Kinase Group: AGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key KZYAHEIPPAPADQ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (>2.2µM at all isozymes tested).
Product References
  1. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases: C.A. Sehon, et al.; J. Med. Chem. 51, 6631 (2008)
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