SYN-1124-M0011 mgCHF 270.00
SYN-1124-M0055 mgCHF 546.00
SYN-1124-M01010 mgCHF 858.00
|Solubility||Soluble in DMSO.|
|Declaration||Manufactured by SynKinase.|
|Other Product Data||
Target: RSK1 - p70S6K | Kinase Group: AGC | Substrate: Serine-Threonine
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (>2.2µM at all isozymes tested).
- Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases: C.A. Sehon, et al.; J. Med. Chem. 51, 6631 (2008)