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SynKinase
GSK25
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | GSK-25 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H16Cl2F2N6O |
| MW | 513.3 |
| CAS | 874119-56-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: RSK1 - p70S6K | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | KZYAHEIPPAPADQ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC(50) of 398nM, p70S6K IC(50) of 1000nM), and a dramatically improved P450 profile (>2.2µM at all isozymes tested).
Product References
- Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases: C.A. Sehon, et al.; J. Med. Chem. 51, 6631 (2008)
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