RO495

CHF 233.00
In stock
SYN-1128-M0011 mgCHF 233.00
SYN-1128-M0055 mgCHF 581.00
SYN-1128-M01010 mgCHF 832.00
SYN-1128-M05050 mgCHF 2'370.00
SYN-1128-M100100 mgCHF 3'818.00
 
More Information
Product Details
Synonyms RO-495
Product Type Chemical
Properties
Formula C17H14Cl2N6O
MW 389.2
CAS 1258296-60-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: TYK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key LNGDQKGREFSTHB-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology.
Product References
  1. Identification of potent Yes1 kinase inhibitors using a library screening approach: P.R. Patel, et al.; Bioorg. Med. Chem. Lett. 23, 4398 (2013)
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