SynKinase

RO495

Name: RO495
Brand: SynKinase
SKU: SYN-1128
Price: 277.00 CHF
Availability: InStock

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Specifications / Handling

More Information
Product Details
Synonyms	RO-495
Product Type	Chemical
Properties
Formula	C₁₇H₁₄Cl₂N₆O
MW	389.2
CAS	1258296-60-4
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: TYK2 \| Kinase Group: PTK \| Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	LNGDQKGREFSTHB-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology.

Product-specific References

Identification of potent Yes1 kinase inhibitors using a library screening approach: P.R. Patel, et al.; Bioorg. Med. Chem. Lett. 23, 4398 (2013)

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