SYN-1128-M0011 mgCHF 277.00
SYN-1128-M0055 mgCHF 688.00
SYN-1128-M01010 mgCHF 986.00
|Solubility||Soluble in DMSO.|
|Declaration||Manufactured by SynKinase.|
|Other Product Data||
Target: TYK2 | Kinase Group: PTK | Substrate: Tyrosine
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology.
- Identification of potent Yes1 kinase inhibitors using a library screening approach: P.R. Patel, et al.; Bioorg. Med. Chem. Lett. 23, 4398 (2013)