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SynKinase
RO495
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | RO-495 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H14Cl2N6O |
| MW | 389.2 |
| CAS | 1258296-60-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: TYK2 | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | LNGDQKGREFSTHB-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology.
Product References
- Identification of potent Yes1 kinase inhibitors using a library screening approach: P.R. Patel, et al.; Bioorg. Med. Chem. Lett. 23, 4398 (2013)
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