R428

CHF 299.00
In stock
SYN-1131-M0011 mgCHF 299.00
SYN-1131-M0055 mgCHF 778.00
SYN-1131-M01010 mgCHF 1'436.00
SYN-1131-M05050 mgCHF 4'668.00
SYN-1131-M100100 mgCHF 7'128.00
 
More Information
Product Details
Synonyms R-428
Product Type Chemical
Properties
Formula C30H34N8
MW 506.6
CAS 1037624-75-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: AKT | Kinase Group: AGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key KXMZDGSRSGHMMK-VWLOTQADSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC(50) values are 11-14nM .
Product References
  1. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer: S.J. Holland, et al.; Cancer Res. 70, 1544 (2010)
  2. Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors: A. Mollard, et al.; ACS Med. Chem. Lett. 2, 907 (2011)
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