SynKinase

R428

Name: R428
Brand: SynKinase
SKU: SYN-1131
Price: 355.00 CHF
Availability: InStock

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Specifications / Handling

More Information
Product Details
Synonyms	R-428
Product Type	Chemical
Properties
Formula	C₃₀H₃₄N₈
MW	506.6
CAS	1037624-75-1
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: AKT \| Kinase Group: AGC \| Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	KXMZDGSRSGHMMK-VWLOTQADSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC(50) values are 11-14nM .

Product-specific References

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer: S.J. Holland, et al.; Cancer Res. 70, 1544 (2010)
Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors: A. Mollard, et al.; ACS Med. Chem. Lett. 2, 907 (2011)

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