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SynKinase
R428
CHF 0.00
In stock
SYN-1131-M0011 mgCHF 355.00
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SYN-1131-M01010 mgCHF 1'703.00
SYN-1131-M05050 mgINQ
SYN-1131-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | R-428 |
| Product Type | Chemical |
| Properties | |
| Formula | C30H34N8 |
| MW | 506.6 |
| CAS | 1037624-75-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: AKT | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | KXMZDGSRSGHMMK-VWLOTQADSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Reported IC(50) values are 11-14nM .
Product References
- R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer: S.J. Holland, et al.; Cancer Res. 70, 1544 (2010)
- Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors: A. Mollard, et al.; ACS Med. Chem. Lett. 2, 907 (2011)
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