JNJ-38158471

CHF 227.00
In stock
SYN-1133-M0011 mgCHF 227.00
SYN-1133-M0055 mgCHF 461.00
SYN-1133-M01010 mgCHF 646.00
SYN-1133-M05050 mgCHF 1'778.00
SYN-1133-M100100 mgCHF 2'568.00
 
More Information
Product Details
Synonyms JNJ38158471
Product Type Chemical
Properties
Formula C15H17ClN6O3
MW 364.8
CAS 951151-97-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: VEGFR-2 | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key BJHCYTJNPVGSBZ-QPSGOUHRSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (>1µM) against VEGFR-1 and VEGFR-3.
Product References
  1. A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo: K.R. LaMontagne, et al.; Angiogenesis 12, 287 (2009)
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