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Product Details
Synonyms SAR-245409
Product Type Chemical
Formula C31H29N5O6S
MW 599.7
CAS 1349796-36-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3K | Kinase Group: Lipid Kinase | Substrate: Lipid

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110α, β, γ and δ, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM)
Product References
  1. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. 27, 5511 (2008)
  2. Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide: G. Prasad, et al.; Neuro Oncol. 13, 384 (2011)
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