AZD-26

CHF 233.00
In stock
SYN-1160-M0011 mgCHF 233.00
SYN-1160-M0055 mgCHF 461.00
SYN-1160-M01010 mgCHF 724.00
SYN-1160-M05050 mgCHF 2'095.00
SYN-1160-M100100 mgCHF 3'280.00
 
More Information
Product Details
Synonyms AZD26
Product Type Chemical
Properties
Formula C22H21N3O
MW 343.4
CAS 1357158-81-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: AKT | Kinase Group: AGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GIRZDHCBMNHMEH-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.
Product References
  1. Diverse heterocyclic scaffolds as allosteric inhibitors of AKT: J.G. Kettle, et al.; J. Med. Chem. 55, 1261 (2012)
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