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SynKinase
AZD-26
CHF 0.00
In stock
SYN-1160-M0011 mgCHF 277.00
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SYN-1160-M01010 mgCHF 858.00
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SYN-1160-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | AZD26 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H21N3O |
| MW | 343.4 |
| CAS | 1357158-81-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: AKT | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GIRZDHCBMNHMEH-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.
Product References
- Diverse heterocyclic scaffolds as allosteric inhibitors of AKT: J.G. Kettle, et al.; J. Med. Chem. 55, 1261 (2012)
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