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SynKinase
PLX4032
71
CHF
CHF 71.00
In stock
SYN-1161-M0011 mgCHF 71.00
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| Product Details | |
|---|---|
| Synonyms | Vemurafenib; RG7204; Zelboraf; RO5185426 |
| Product Type | Chemical |
| Properties | |
| Formula | C23H18ClF2N3O3S |
| MW | 489.9 |
| CAS | 918504-65-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Raf | Kinase Group: TKL | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GPXBXXGIAQBQNI-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with an IC(50) of 31nM.
Product References
- BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells: E. Sala, et al.; Mol. Cancer Res. 6, 751 (2008)
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