PLX4720

CHF 100.00
In stock
AG-CR1-3577-M0055 mgCHF 100.00
AG-CR1-3577-M02525 mgCHF 330.00
More Information
Product Details
Synonyms N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Product Type Chemical
Properties
Formula

C17H14ClF2N3O3S

MW 413.8
CAS 918505-84-7
Source/Host Chemicals Synthetic.
Purity Chemicals ≥99% (HPLC)
Appearance Off-white solid.
Solubility Soluble in DMSO or ethanol.
InChi Key YZDJQTHVDDOVHR-UHFFFAOYSA-N
Smiles CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=NC=C(Cl)C=C23)=C1F
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor.
  • Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
Product References
  1. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity: J. Tsai, et al.; PNAS 105, 3041(2008)
  2. Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival: R.A. Cartlidge, et al.; Pigment Cell Melanoma Res. 21, 534 (2008)
  3. Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma: L.M. Packer, et al.; Pigment Cell Melanoma Res. 22, 785 (2009)
  4. Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells: P. Salerno, et al.; J. Clin. Endocrinol. Metab. 95, 450 (2010)
  5. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression: C. Nucera, et al.; PNAS 107, 10649 (2010)
  6. Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS: C.C. Jiang, et al.; Cell Death Dis. 1, e69 (2010)
  7. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer: C. Nucera, et al.; Oncologist 16, 296 (2011)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.