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AdipoGen Life Sciences
PLX4720
95
CHF
CHF 95.00
In stock
AG-CR1-3577-M0055 mgCHF 95.00
AG-CR1-3577-M02525 mgCHF 300.00
| Product Details | |
|---|---|
| Synonyms | N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H14ClF2N3O3S |
| MW | 413.8 |
| CAS | 918505-84-7 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO or ethanol. |
| InChi Key | YZDJQTHVDDOVHR-UHFFFAOYSA-N |
| Smiles | CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=NC=C(Cl)C=C23)=C1F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor.
- Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
Product References
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity: J. Tsai, et al.; PNAS 105, 3041(2008)
- Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival: R.A. Cartlidge, et al.; Pigment Cell Melanoma Res. 21, 534 (2008)
- Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma: L.M. Packer, et al.; Pigment Cell Melanoma Res. 22, 785 (2009)
- Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells: P. Salerno, et al.; J. Clin. Endocrinol. Metab. 95, 450 (2010)
- B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression: C. Nucera, et al.; PNAS 107, 10649 (2010)
- Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS: C.C. Jiang, et al.; Cell Death Dis. 1, e69 (2010)
- Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer: C. Nucera, et al.; Oncologist 16, 296 (2011)
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