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SynKinase
Takeda-6d
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | Takeda 6d |
| Product Type | Chemical |
| Properties | |
| Formula | C27H19ClFN5O3S |
| MW | 548.0 |
| CAS | 1125632-93-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: B-RAF - VEGFR2 | Kinase Group: TKL | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MDPMAXSABUPRJI-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM.
Product References
- Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds: M. Okaniwa, et al.; J. Med. Chem. 55, 3452 (2012)
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