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Product Details
Synonyms GCI-1746; G-182
Product Type Chemical
Formula C34H37N5O4
MW 579.7
CAS 910232-84-7
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: BTK | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.
Product References
  1. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis: J.A. Di Paolo, et al.; Nat. Chem. Biol. 7, 41 (2011)
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