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SynKinase
GCI1746
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | GCI-1746; G-182 |
| Product Type | Chemical |
| Properties | |
| Formula | C34H37N5O4 |
| MW | 579.7 |
| CAS | 910232-84-7 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: BTK | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | JIFCFQDXHMUPGP-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.
Product References
- Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis: J.A. Di Paolo, et al.; Nat. Chem. Biol. 7, 41 (2011)
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