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SynKinase
AZD-8055
85
CHF
CHF 85.00
In stock
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| Product Details | |
|---|---|
| Synonyms | AZD8055; CCG168 |
| Product Type | Chemical |
| Properties | |
| Formula | C25H31N5O4 |
| MW | 465.5 |
| CAS | 1009298-09-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: mTOR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | KVLFRAWTRWDEDF-IRXDYDNUSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC(50) of 0.8nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family.
Product References
- Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment: C. Garcia-Echeverria; Bioorg. Med. Chem. Lett. 20, 4308 (2010)
- Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014: K.G. Pike, et al.; Bioorg. Med. Chem. Lett. 23, 1212 (2013)
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