SynKinase

Regorafenib

Name: Regorafenib
Brand: SynKinase
SKU: SYN-1169
Price: 114.00 CHF
Availability: InStock

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Specifications / Handling

More Information
Product Details
Synonyms	BAY-73-4506
Product Type	Chemical
Properties
Formula	C₂₁H₁₅ClF₄N₄O₃
MW	482.8
CAS	755037-03-7
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: VEGFR \| Kinase Group: RTK \| Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	FNHKPVJBJVTLMP-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively.

Product-specific References

Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity: S.M. Wilhelm, et al.; Int. J. Cancer 129, 245 (2011)

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