GSK1120212

CHF 96.00
In stock
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More Information
Product Details
Synonyms JTP-74057; GSK212; Trametinib
Product Type Chemical
Properties
Formula C26H23FIN5O4
MW 615.4
CAS 871700-17-3
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: MEK1 - MEK2 | Kinase Group: STE | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively.
Product References
  1. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition: A.G. Gilmartin, et al.; Clin. Cancer Res. 17, 989 (2011)
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