Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
GSK1120212
INQ
In stock
SYN-1170-M0011 mgCHF 114.00
SYN-1170-M0055 mgCHF 163.00
SYN-1170-M01010 mgCHF 291.00
SYN-1170-M05050 mgCHF 915.00
SYN-1170-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | JTP-74057; GSK212; Trametinib |
| Product Type | Chemical |
| Properties | |
| Formula | C26H23FIN5O4 |
| MW | 615.4 |
| CAS | 871700-17-3 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: MEK1 - MEK2 | Kinase Group: STE | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively.
Product References
- GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition: A.G. Gilmartin, et al.; Clin. Cancer Res. 17, 989 (2011)
Related Products
