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Product Details
Synonyms SGI1776
Product Type Chemical
Formula C20H22F3N5O
MW 405.4
CAS 1025065-69-3
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Pim1 - Pim2 - Pim3 | Kinase Group: CAMK | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. SGI-1776 inhibits FLT3 kinase as well, which can complicate some experimental results if not carefully controlled.
Product References
  1. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia: L.S. Chen, et al.; Blood 118, 693 (2011)
  2. Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors: J. Pastor, et al.; Bioorg. Med. Chem. Lett. 22, 1591 (2012)
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