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SynKinase
SGI-1776
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | SGI1776 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H22F3N5O |
| MW | 405.4 |
| CAS | 1025065-69-3 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Pim1 - Pim2 - Pim3 | Kinase Group: CAMK | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MHXGEROHKGDZGO-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. SGI-1776 inhibits FLT3 kinase as well, which can complicate some experimental results if not carefully controlled.
Product References
- Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia: L.S. Chen, et al.; Blood 118, 693 (2011)
- Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors: J. Pastor, et al.; Bioorg. Med. Chem. Lett. 22, 1591 (2012)
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