SYN-1194-M0011 mgCHF 277.00
SYN-1194-M0055 mgCHF 546.00
SYN-1194-M01010 mgCHF 858.00
|Solubility||Soluble in DMSO.|
|Declaration||Manufactured by SynKinase.|
|Other Product Data||
Target: PI3K - mTOR | Kinase Group: Lipid Kinase | Substrate: Lipid
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
|Use/Stability||Stable for at least 1 year after receipt when stored at +4°C.|
|Product Specification Sheet|
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kα (Ki= 0.13nM human, 0.299nM mouse) and PI3Kγ (Ki=0.111nM), and PI3Kδ (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
- Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design: H. Cheng, et al.; ACS Med. Chem. Lett. 4, 91 (2012)