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SynKinase
PF-04979064
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | PF04979064 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H26N6O3 |
| MW | 446.5 |
| CAS | 1220699-06-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PI3K - mTOR | Kinase Group: Lipid Kinase | Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GACQNUHFDBEIQH-HNNXBMFYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kα (Ki= 0.13nM human, 0.299nM mouse) and PI3Kγ (Ki=0.111nM), and PI3Kδ (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
Product References
- Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design: H. Cheng, et al.; ACS Med. Chem. Lett. 4, 91 (2012)
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