PF-04979064

CHF 233.00
In stock
SYN-1194-M0011 mgCHF 233.00
SYN-1194-M0055 mgCHF 461.00
SYN-1194-M01010 mgCHF 724.00
SYN-1194-M05050 mgCHF 2'436.00
SYN-1194-M100100 mgCHF 3'884.00
 
More Information
Product Details
Synonyms PF04979064
Product Type Chemical
Properties
Formula C24H26N6O3
MW 446.5
CAS 1220699-06-8
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3K - mTOR | Kinase Group: Lipid Kinase | Substrate: Lipid

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key GACQNUHFDBEIQH-HNNXBMFYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kα (Ki= 0.13nM human, 0.299nM mouse) and PI3Kγ (Ki=0.111nM), and PI3Kδ (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
Product References
  1. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design: H. Cheng, et al.; ACS Med. Chem. Lett. 4, 91 (2012)
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