GDC-046

CHF 108.00
In stock
SYN-1198-M0011 mgCHF 108.00
SYN-1198-M0055 mgCHF 180.00
SYN-1198-M01010 mgCHF 287.00
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More Information
Product Details
Synonyms GDC046
Product Type Chemical
Properties
Formula C16H13Cl2N3O2
MW 350.2
CAS 1258292-64-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: TYK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key IAFNAEGXTKTGHN-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.
Product References
  1. Lead identification of novel and selective TYK2 inhibitors: J. Liang, et al.; Eur. J. Med. Chem. 67, 175 (2013)
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