SynKinase

BKM120

As low as CHF 85.00

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SYN-1200-M0011 mgCHF 85.00

SYN-1200-M0055 mgCHF 128.00

SYN-1200-M01010 mgCHF 170.00

SYN-1200-M05050 mgCHF 553.00

SYN-1200-M100100 mgCHF 922.00

Specifications / Handling

More Information
Product Details
Synonyms	NVP-BKM120
Product Type	Chemical
Properties
Formula	C₁₈H₂₁F₃N₆O₂
MW	410.4
CAS	944396-07-0
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: PI3K - mTOR \| Kinase Group: Lipid Kinase \| Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	CWHUFRVAEUJCEF-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kα Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks.

Product-specific References

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)

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