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SynKinase
BKM120
85
CHF
CHF 85.00
In stock
SYN-1200-M0011 mgCHF 85.00
SYN-1200-M0055 mgCHF 128.00
SYN-1200-M01010 mgCHF 170.00
SYN-1200-M05050 mgCHF 553.00
SYN-1200-M100100 mgCHF 922.00
| Product Details | |
|---|---|
| Synonyms | NVP-BKM120 |
| Product Type | Chemical |
| Properties | |
| Formula | C18H21F3N6O2 |
| MW | 410.4 |
| CAS | 944396-07-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PI3K - mTOR | Kinase Group: Lipid Kinase | Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | CWHUFRVAEUJCEF-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kα Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks.
Product References
- Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)
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