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SynKinase
GDC-0032
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | GDC0032 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H28N8O2 |
| MW | 460.5 |
| CAS | 1282512-48-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Slightly soluble (<1mg/ml) in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PI3K | Kinase Group: Lipid Kinases | Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | BEUQXVWXFDOSAQ-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29nM/0.12nM/0.97nM, >10 fold selective over PI3Kβ.
Product References
- Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity: C.O. Ndubaku, et al.; J. Med. Chem. 56, 4597 (2013)
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