GDC-0032

CHF 96.00
In stock
SYN-1202-M0011 mgCHF 96.00
SYN-1202-M0055 mgCHF 144.00
SYN-1202-M01010 mgCHF 239.00
SYN-1202-M05050 mgCHF 778.00
SYN-1202-M100100 mgCHF 1'185.00
 
More Information
Product Details
Synonyms GDC0032
Product Type Chemical
Properties
Formula C24H28N8O2
MW 460.5
CAS 1282512-48-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Slightly soluble (<1mg/ml) in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3K | Kinase Group: Lipid Kinases | Substrate: Lipid

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29nM/0.12nM/0.97nM, >10 fold selective over PI3Kβ.
Product References
  1. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity: C.O. Ndubaku, et al.; J. Med. Chem. 56, 4597 (2013)
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