TASP0415914

CHF 180.00
In stock
SYN-1208-M0011 mgCHF 180.00
SYN-1208-M0055 mgCHF 347.00
SYN-1208-M01010 mgCHF 503.00
SYN-1208-M05050 mgCHF 1'616.00
SYN-1208-M100100 mgCHF 2'693.00
 
More Information
Product Details
Synonyms TASP-0415914
Product Type Chemical
Properties
Formula C13H17N5O3S
MW 323.4
CAS 1292300-75-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3Kγ

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key WFQFHKQIDOCQTL-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PI3Kγ is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Kγ IC(50) 29nM, AKT IC(50) 294nM.
Product References
  1. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases: Y. Oka, et al.; Bioorg. Med. Chem. 21, 7578 (2013)
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