GSK-F1

CHF 144.00
In stock
SYN-1220-M0011 mgCHF 144.00
SYN-1220-M0055 mgCHF 299.00
SYN-1220-M01010 mgCHF 467.00
SYN-1220-M05050 mgCHF 1'496.00
SYN-1220-M100100 mgCHF 2'334.00
 
More Information
Product Details
Synonyms 5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide; GSKF1
Product Type Chemical
Properties
Formula C27H18F5N5O4S
MW 603.5
CAS 1402345-92-9
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI4KA | Kinase Group: PIKK | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key MSRFVAYVUUHQCN-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.
Product References
  1. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels: N. Bojjireddy, et al.; J. Biol. Chem. 289, 6120 (2014)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.