GSK-A1

CHF 144.00
In stock
SYN-1219-M0011 mgCHF 144.00
SYN-1219-M0055 mgCHF 299.00
SYN-1219-M01010 mgCHF 467.00
SYN-1219-M05050 mgCHF 1'496.00
SYN-1219-M100100 mgCHF 2'334.00
 
More Information
Product Details
Synonyms 5-(2-Amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide; GSKA1
Product Type Chemical
Properties
Formula C29H27FN6O4S
MW 574.6
CAS 1416334-69-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI4KA | Kinase Group: PIKK | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key AJOGHKUZDLYXKS-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.
Product References
  1. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels: N. Bojjireddy, et al.; J. Biol. Chem. 289, 6120 (2014)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.