BBT594

CHF 227.00
In stock
SYN-1225-M0011 mgCHF 227.00
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More Information
Product Details
Synonyms BBT-594
Product Type Chemical
Properties
Formula C28H30F3N7O3
MW 569.6
CAS 882405-89-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: JAK2 | Kinase Group: PTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key VQLNKQZLPGLOSI-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase inhibitor (AI) treatment and reverts AI resistance. In murine models, the IC50 of BBT594 on JAK2 inhibition varies between 8nM - 29nM, depending on the cell model and abundant JAK2 mutations.
Product References
  1. Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent: R. Andraos, et al.; Cancer Discov. 2, 512 (2012)
  2. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors: A. Morandi, et al.; Cancer Res. 73, 3783 (2013)
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