Bayer-18

CHF 227.00
In stock
SYN-1130-M0011 mgCHF 227.00
SYN-1130-M0055 mgCHF 581.00
SYN-1130-M01010 mgCHF 832.00
SYN-1130-M05050 mgCHF 2'370.00
SYN-1130-M100100 mgCHF 3'818.00
 
More Information
Product Details
Synonyms Bayer18
Product Type Chemical
Properties
Formula C19H27FN6O2
MW 390.5
CAS 1251752-12-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: TYK2 | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key DYNMZYFOSRSMAC-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Bayer-18 is a selective TYK2 inhibitor, with an IC(50) of 18.7nM on TYK2 as measured by TYK2 HTRF assays. The compound shows 1000 fold selectivity against JAK2, CDK and KDR kinases in similar HTRF assays.
Product References
  1. New phenyl-pyrimidin-2-yl-amine compounds are tyrosine kinase 2 inhibitors useful for treating E.G. rheumatoid arthritis, Crohn's disease, asthma, multiple sclerosis, adult respiratory distress syndrome, allergic alveolitis and uveitis: B. Buchmann, et al.; DE102009015070 (2010)
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