Selonsertib . hydrochloride

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SYN-1229-M0011 mgCHF 128.00
SYN-1229-M0055 mgCHF 270.00
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SYN-1229-M100100 mgINQ
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Product Details
Synonyms GS-4997
Product Type Chemical
Formula C24H24FN7O . HCl
MW 445.5 . 36.5
CAS 1448428-05-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: ASK1 | Kinase Group: Ser/Thr Kinases |

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.

Product References
  1. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease: J.H. Lin, et al.; Nephron 129, 29 (2015)
  2. A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study: C.H. Nelson, et al.; Clin. Pharmacol. Ther. 98, 630 (2015)
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