|Solubility||Soluble in DMSO.|
|Declaration||Manufactured by SynKinase.|
|Other Product Data||
Target: BRPF1 | Kinase Group: N/A | Substrate: N/A
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues 1-21). PFI-4 is potent in cells, with an IC50 value of 250nM.
- 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain: E.H. Demont, et al.; ACS Med. Chem. Lett. 5, 1190 (2014)