PFI-4

CHF 60.00
In stock
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Product Details
Synonyms N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide
Product Type Chemical
Properties
Formula C21H24N4O3
MW 380.5
CAS 900305-37-5
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: BRPF1 | Kinase Group: N/A | Substrate: N/A

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key QCIJLRJBZDBVDB-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues 1-21). PFI-4 is potent in cells, with an IC50 value of 250nM.
Product References
  1. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain: E.H. Demont, et al.; ACS Med. Chem. Lett. 5, 1190 (2014)
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