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SYN-3048-M0011 mgCHF 99.00
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Product Details
Synonyms 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
Product Type Chemical
Formula C20H27N3O5S
MW 421.5
CAS 1370888-71-3
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: BRD2 - BRD3 - BRD4 | Kinase Group: N/A | Substrate: N/A
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd values of 1.2, 1.6, 2.6 and 3.7μM, respectively. XD14 has shown to attenuate proliferation of HL-60 leukemia cells in vitro.

Product References
  1. 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading: X. Lucas, et al.; Angew. Chem. Int. Ed. Engl. 52, 14055 (2013)
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