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XD14
INQ
In stock
SYN-3048-M0011 mgCHF 99.00
SYN-3048-M0055 mgCHF 170.00
SYN-3048-M01010 mgCHF 284.00
SYN-3048-M05050 mgCHF 922.00
SYN-3048-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide |
| Product Type | Chemical |
| Properties | |
| Formula | C20H27N3O5S |
| MW | 421.5 |
| CAS | 1370888-71-3 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data | Target: BRD2 - BRD3 - BRD4 | Kinase Group: N/A | Substrate: N/A |
| InChi Key | DPBKLIVPNYGQQG-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd values of 1.2, 1.6, 2.6 and 3.7μM, respectively. XD14 has shown to attenuate proliferation of HL-60 leukemia cells in vitro.
Product References
- 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading: X. Lucas, et al.; Angew. Chem. Int. Ed. Engl. 52, 14055 (2013)
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