XD14

CHF 84.00
In stock
SYN-3048-M0011 mgCHF 84.00
SYN-3048-M0055 mgCHF 144.00
SYN-3048-M01010 mgCHF 239.00
SYN-3048-M05050 mgCHF 778.00
SYN-3048-M100100 mgCHF 1'257.00
 
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Product Details
Synonyms 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
Product Type Chemical
Properties
Formula C20H27N3O5S
MW 421.5
CAS 1370888-71-3
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: BRD2 - BRD3 - BRD4 | Kinase Group: N/A | Substrate: N/A

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key DPBKLIVPNYGQQG-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd values of 1.2, 1.6, 2.6 and 3.7μM, respectively. XD14 has shown to attenuate proliferation of HL-60 leukemia cells in vitro.
Product References
  1. 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading: X. Lucas, et al.; Angew. Chem. Int. Ed. Engl. 52, 14055 (2013)
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