AdipoGen Life Sciences

anti-IL-23p19 (human), mAb (I 178G)

CHF 110.00

In stock

AG-20A-0027-C05050 µgCHF 110.00

AG-20A-0027-C100100 µgCHF 190.00

Figure 1: Western blot analysis using anti-IL-23p19 (human), mAb (I 178G) (Prod. No. AG-20A-0027) at 1:2'000 dilution.
1: Human IL-23p19 Fc-fusion protein.
2: Recombinant human single chain IL-23 (FLAG^®-tagged).

Specifications / Handling

More Information
Product Details
Synonyms	Interleukin-23 Subunit p19; Interleukin-23 Subunit α; IL-23-A
Product Type	Monoclonal Antibody
Properties
Clone	I 178G
Isotype	Rat IgG2aκ
Immunogen/Antigen	Recombinant human IL-23p19.
Application	ELISA: (direct or indirect: 1:2'000-1:10'000) Western blot: (1:2'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application. Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS.
Crossreactivity	Human
Specificity	Recognizes human IL-23p19.
Purity Detail	Protein G-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control	Rat IgG2a Isotype Control
RRID	AB_2490109
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

IL-23p19 associates with IL-12b to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

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