AdipoGen Life Sciences

anti-RELM-α (mouse), mAb (MREL 127)

CHF 110.00

In stock

AG-20A-0060-C05050 µgCHF 110.00

Figure 1: Western blot analysis using anti-RELM-α (mouse), mAb (MREL 127) (Prod. No. AG-20A-0060) at 1:5'000 dilution.
1: Mouse RELM-α (His-tagged).
2: Mouse RELM-α Fc-protein.

Specifications / Handling

More Information
Product Details
Synonyms	Resistin-like Molecule-α FIZZ1; PMNG1; HIMF
Product Type	Monoclonal Antibody
Properties
Clone	MREL 127
Isotype	Rat IgG2aκ
Immunogen/Antigen	Recombinant mouse RELM-α.
Application	ELISA: (direct or indirect: 1:5'000-1:10'000) Western blot: (1:5'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application. Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS.
Crossreactivity	Mouse
Specificity	Recognizes mouse RELM-α. Detects a band of ~10kDa by Western blot.
Purity Detail	Protein G-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Other Product Data	Rat IgG2a Isotype Control
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

RELM-α is a member to the family of adipocyte-secreted proteins called adipocytokines. It is abundantly expressed in white adipose tissue but not in preadipocytes, nor 3T3-L1 adipocytes. RELM-α is involved in the regulation of colonic inflammation and might be a link between colonic injury, glucose tolerance, and energy intake. Recently, RELM-α (from epidermis) has been shown to be induced by skin microbiota. The function of RELM-α is to kill bacteria of the skin via membrane disruption. RELM-α is induced by vitamin A and explains the mechanism by which vitamin A regulates skin immunity.

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