AdipoGen Life Sciences

anti-RELM-α (mouse), mAb (MREL 127)

CHF 110.00
In stock
AG-20A-0060-C05050 µgCHF 110.00
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Product Details
Synonyms Resistin-like Molecule-α FIZZ1; PMNG1; HIMF
Product Type Monoclonal Antibody
Properties
Clone MREL 127
Isotype Rat IgG2aκ
Immunogen/Antigen Recombinant mouse RELM-α.
Application

ELISA: (direct or indirect: 1:5'000-1:10'000)
Western blot: (1:5'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature).
Optimal conditions should be determined individually for each application.

Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS.

Crossreactivity Mouse
Specificity

Recognizes mouse RELM-α. Detects a band of ~10kDa by Western blot.

Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Other Product Data

Rat IgG2a Isotype Control

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

RELM-α is a member to the family of adipocyte-secreted proteins called adipocytokines. It is abundantly expressed in white adipose tissue but not in preadipocytes, nor 3T3-L1 adipocytes. RELM-α is involved in the regulation of colonic inflammation and might be a link between colonic injury, glucose tolerance, and energy intake. Recently, RELM-α (from epidermis) has been shown to be induced by skin microbiota. The function of RELM-α is to kill bacteria of the skin via membrane disruption. RELM-α is induced by vitamin A and explains the mechanism by which vitamin A regulates skin immunity.

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