AdipoGen Life Sciences

anti-RELM-α (mouse), pAb

CHF 190.00

In stock

AG-25A-0010-C100100 µgCHF 190.00

Figure 1: Western blot analysis using anti-RELM-α (mouse), pAb (Prod. No. AG-25A-0010) at 1:5'000 dilution.
1: Mouse RELM-α.
2: Mouse RELM-α Fc-protein.

Specifications / Handling

More Information
Product Details
Synonyms	Resistin-like molecule-α; FIZZ1; PMNG1; HIMF
Product Type	Polyclonal Antibody
Properties
Source/Host	Rabbit
Immunogen/Antigen	Recombinant mouse RELM-α.
Application	ELISA: (direct and indirect: 1:5’000-1:10’000) Western Blot: (1:5’000-1:10’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application. Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS.
Crossreactivity	Mouse
Specificity	Recognizes mouse RELM-α. Weakly cross-reacts with rat RELM-α. Detects a band of ~9.5kDa by Western blot.
Purity Detail	Protein A-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control	Rabbit IgG
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

RELM-α is a member to the family of adipocyte-secreted proteins called adipocytokines. It is abundantly expressed in white adipose tissue but not in preadipocytes, nor 3T3-L1 adipocytes. RELM-α is involved in the regulation of colonic inflammation and might be a link between colonic injury, glucose tolerance, and energy intake. Recently, RELM-α (from epidermis) has been shown to be induced by skin microbiota. The function of RELM-α is to kill bacteria of the skin via membrane disruption. RELM-α is induced by vitamin A and explains the mechanism by which vitamin A regulates skin immunity.

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