AdipoGen Life Sciences

anti-VEGF-A (human), mAb (3(6D3))

As low as CHF 470.00

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AG-20T-0105-C200200 µgCHF 470.00

Specifications / Handling

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Product Details
Synonyms	Vascular Endothelial Growth Factor-A; VPF
Product Type	Monoclonal Antibody
Properties
Clone	3(6D3)
Isotype	Mouse IgG1
Immunogen/Antigen	Recombinant human VEGF 165.
Application	ELISA: (1-15μg/ml) Functional Application: Neutralization. Inhibits VEGF-A signaling. Western Blot: (2-10μg/ml) Optimal conditions must be determined individually for each application.
Crossreactivity	Human
Purity	Protein G purified.
Purity Detail	Protein G purified.
Formulation	Lyophilized from a buffer containing Trehalose, Na-Phosphate and Polysorbat 20.
Reconstitution	Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml.
Isotype Negative Control	Mouse IgG1 Isotype Control
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Human vascular endothelial growth factor (VEGF 165) is produced as a homodimer. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. VEGF-A is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. It is also a chemoattractant molecule for monocytes and endothelial cells. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.

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