AdipoGen Life Sciences

anti-Cornulin (human), pAb (SZ1229)

Name: anti-Cornulin (human), pAb (SZ1229)
Brand: AdipoGen Life Sciences
SKU: AG-25B-0016
Price: 240.00 CHF
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AG-25B-0016-C05050 µgCHF 240.00

Figure 1: Immunohistochemistry detection of human cornulin using anti-Cornulin (human), pAb (SZ1229) (Prod. No. AG-25B-0016). Method: Staining performed on frozen sections of esophagus (H), foreskin (A-C) and scalp (D-G) using anti-Cornulin (human), pAb (SZ1229) at 1:100 in PBS containing 12% BSA. Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle (arrows, D–F), in normal esophagus, the staining is localized in the granular and lower cornified cell layers with a peripheral localization (arrows). Control sections (C and G) show no staining.

Specifications / Handling

More Information
Product Details
Synonyms	Tumor Related Protein; C1orf10 Gene Product; Chromosome 1 Open Reading Frame 10 Gene Product
Product Type	Polyclonal Antibody
Properties
Source/Host	Rabbit
Immunogen/Antigen	Synthetic peptide corresponding to aa 259-274 (E²⁵⁹ATNDQNRGTETHGQG²⁷⁴) of human cornulin.
Application	Immunohistochemistry: (frozen sections: 1:100) Western Blot: (1:2'000)
Crossreactivity	Human
Specificity	Recognizes human cornulin. Detects a band of ~70kDa by Western blot.
Concentration	0.5mg/ml
Formulation	Liquid. In PBS containing 1% BSA and 0.01% sodium azide.
Isotype Negative Control	Rabbit IgG
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines. It attenuates deoxycholic acid (DCA)-induced apoptotic cell death and the release of calcium. In overexpressed oral squamous carcinoma cell lines, cornulin negatively regulates cell proliferation by the induction of G1 arrest.

Product-specific References

Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation: R. Contzler, et al.; J. Invest. Dermatol. 124, 990 (2005)

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