AdipoGen Life Sciences

anti-GLUT2 (rat), pAb (IN119)

CHF 240.00
In stock
AG-25B-0043-C05050 µgCHF 240.00
More Information
Product Details
Synonyms Solute Carrier Family 2, Facilitated Glucose Transporter Member 2; SLC2A2; Glucose Transporter Type 2, Liver
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen A synthetic peptide corresponding to 10 aa located near the C-terminus of rat GLUT2.
Application

Western Blot: (1:500)*
Immunohistochemistry: (1:200)
Immunoprecipitation:
*Note: We recommend a starting dilution of 1:500 and optimize the dilution depending on the type of cells/tissues.

Crossreactivity Rat
Specificity

Recognizes rat GLUT2.

Purity ≥95% (SDS-PAGE)
Purity Detail Protein A affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% Proclin 300.
Isotype Negative Control

Rabbit IgG Isotype control

Other Product Data

UniProt link P12336 : GLUT2 (rat)

Accession Number P12336
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

GLUT2 belongs to the family of glucose transporters (GLUTs, encoded by the SLC2A genes), which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose (Km ~ 17mmol/l), and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine (Km ~ 0.8mmol/l).

GLUT2 is expressed in liver, intestine, kidney and pancreatic islet β cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes.

In pancreatic β cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose-sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.

Product References
  1. Reduced expression of the liver/beta cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats: B. Thorens, et al.; PNAS 87, 6492 (1990)
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