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AdipoGen Life Sciences
anti-GLUT2 (rat), pAb (IN119)
240
CHF
CHF 240.00
In stock
AG-25B-0043-C05050 µgCHF 240.00
Figure 1: Detection of endogenous rat GLUT2 in rat liver membranes by immunoblotting using anti-GLUT2 (rat), pAb (IN119) (Prod. No. AG-25B-0043).
| Product Details | |
|---|---|
| Synonyms | Solute Carrier Family 2, Facilitated Glucose Transporter Member 2; SLC2A2; Glucose Transporter Type 2, Liver |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | A synthetic peptide corresponding to 10 aa located near the C-terminus of rat GLUT2. |
| Application |
Western Blot: (1:500)* |
| Crossreactivity | Rat |
| Specificity |
Recognizes rat GLUT2. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein A affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% Proclin 300. |
| Isotype Negative Control | |
| Other Product Data |
UniProt link P12336 : GLUT2 (rat) |
| Accession Number | P12336 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GLUT2 belongs to the family of glucose transporters (GLUTs, encoded by the SLC2A genes), which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose (Km ~ 17mmol/l), and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine (Km ~ 0.8mmol/l).
GLUT2 is expressed in liver, intestine, kidney and pancreatic islet β cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes.
In pancreatic β cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose-sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.
Product References
- Reduced expression of the liver/beta cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats: B. Thorens, et al.; PNAS 87, 6492 (1990)
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