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Solute Carrier Family 2, Facilitated Glucose Transporter Member 2; SLC2A2; Glucose Transporter Type 2, Liver
Product Type
Polyclonal Antibody
Properties
Source/Host
Rabbit
Immunogen/Antigen
A synthetic peptide corresponding to 10 aa located near the C-terminus of rat GLUT2.
Application
Western Blot: (1:500)* Immunohistochemistry: (1:200) Immunoprecipitation: *Note: We recommend a starting dilution of 1:500 and optimize the dilution depending on the type of cells/tissues.
Crossreactivity
Rat
Specificity
Recognizes rat GLUT2.
Purity
≥95% (SDS-PAGE)
Purity Detail
Protein A affinity purified.
Concentration
1mg/ml
Formulation
Liquid. In PBS containing 10% glycerol and 0.02% Proclin 300.
GLUT2 belongs to the family of glucose transporters (GLUTs, encoded by the SLC2A genes), which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose (Km ~ 17mmol/l), and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine (Km ~ 0.8mmol/l).
GLUT2 is expressed in liver, intestine, kidney and pancreatic islet β cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes.
In pancreatic β cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose-sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.
Product References
Reduced expression of the liver/beta cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats: B. Thorens, et al.; PNAS 87, 6492 (1990)
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