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AdipoGen Life Sciences
anti-NFATc2 (human), pAb (IG-209)
As low as
570
CHF
CHF 570.00
In stock
Only %1 left
AG-25T-0111-C02020 µgCHF 570.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Nuclear Factor of Activated T Cells; Cytoplasmic 2; NF-ATc2; NF-ATp |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant full-length human NFATc2 fused to a GST-tag. |
| Application |
ChIP: (1:100) |
| Crossreactivity | Human |
| Specificity |
Recognizes human NFATc2. |
| Purity | Antigen affinity purified. |
| Concentration | 200μg/ml |
| Formulation | Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. |
| Isotype Negative Control | |
| Accession Number | UniProt ID Q13469: NFATc2 human |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
NFATc2 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of IL-2, IL-3, IL-4, TNF-α or GM-CSF. It promotes invasive migration through the activation of GPC6 expression and the WNT5A signaling pathway.
Product-specific References
- Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006)
- Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008)
- Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter: S. Klein-Hessling, et al.; J. Biol. Chem. 283, 31030 (2008)
- NFAT but not NF-B is critical for transcriptional induction of the pro-survival gene A1 following igE receptor activation in mast cells: E. Ulleras, et al.; Blood 111, 3081 (2008)
- Autoregulation of Th1-mediated inflammation by twist1: U. Niesner, et al.; J. Exp. Med. 205, 1889 (2008)
- CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation: I. Zanoni, et al.; Nature 460, 264 (2009)
- Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells: H. Flach, et al.; Immunity 33, 723 (2010)
- NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network: S. Bhattacharyya, et al.; J. Exp. Med. 208, 823 (2011)
- Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis: K. Gerlach, et al.; Cancer Res. 72, 4340 (2012)
- Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells: M. Vaeth, et al.; PNAS 109, 16258 (2012)
- An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development: A.K. Patra, et al.; Nat. Immunol. 14, 127 (2013)
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