AdipoGen Life Sciences

Jagged-1 (mouse):Fc (human) (rec.)

CHF 235.00
In stock
AG-40A-0157T-C01010 µgCHF 235.00
AG-40A-0157T-C05050 µgCHF 480.00
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Product Details
Synonyms Protein Jagged-1; CD339; JAG1
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

Signal peptide and extracellular domain of mouse Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG.

Crossreactivity Mouse
Biological Activity

Inhibits adipogenesis of 3T3L-1 cells.

MW ~150kDa (SDS-PAGE)
Purity ≥90% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration For 10μg size: 0.1 mg /ml after reconstitution.
For 50μg size: 1mg/ml after reconstitution.
Reconstitution For 10μg size: reconstitute with 100μl sterile water.
For 50μg size: reconstitute with 50μl sterile water.
Formulation Lyophilized. Contains PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

UniProt link Q9QXX0: JAG1 (mouse)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).

Product References
  1. Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity: H. Sakai, et al.; PLoS ONE 12, e0177516 (2017)
  2. Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression: Z. Martinez-Lozada & M.B. Robinson; Neurochem. Int. 139, 104787 (2020)
  3. Essential role of MALAT1 in reducing traumatic brain injury: N. Wu, et al.; Neural Regen. Res. 17, 1776 (2022)
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