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AdipoGen Life Sciences
GITR (mouse):Fc (human) (rec.)
350
CHF
CHF 350.00
In stock
AG-40B-0002-C05050 µgCHF 350.00
AG-40B-0002-30503 x 50 µgCHF 695.00
| Product Details | |
|---|---|
| Synonyms | Tumor Necrosis Factor Receptor Superfamily Member 18; Activation-inducible TNFR Family Receptor; Glucocorticoid-induced TNFR-related Protein; CD357; TNFRSF18; AITR |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Mouse GITR (aa 20-152) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Mouse |
| Specificity |
Binds to mouse GITRL. |
| MW | ~45kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
UniProt link O35714: GITR (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GITR (Glucocorticoid-induced TNF receptor) is the receptor for TNFSF18. It is involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T cell receptor-mediated cell death. GITR serves as a negative regulator for NK cell activation. It mediates NF-κB activation via the TRAF2/NIK pathway.
Product References
- Engineered Alginate Microcapsules for Molecular Therapy Through Biologic Secreting Cells: P. Montanucci, et al.; Tissue Eng. Part C Methods 25, 296 2019)
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