DR6 (human):Fc (human) (recombinant protein)

Specifications / Handling

More Information
Product Details
Synonyms	Tumor Necrosis Factor Receptor Superfamily Member 21; TNFRSF21; Death Receptor 6; CD358
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).
Crossreactivity	Human
MW	~80kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.1EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml after reconstitution.
Reconstitution	Reconstitute with 50μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Formulation	Lyophilized. Contains PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	Uni-Prot link O75509: DR6 (human)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the β-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

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DR6 (human):Fc (human) (rec)