Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
DR6 (human):Fc (human) (rec)
As low as
170
CHF
CHF 170.00
In stock
Only %1 left
AG-40B-0011-C05050 µgCHF 170.00
AG-40B-0011-30503 x 50 µgCHF 340.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Tumor Necrosis Factor Receptor Superfamily Member 21; TNFRSF21; Death Receptor 6; CD358 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351). |
| Crossreactivity | Human |
| MW | ~80kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
Uni-Prot link O75509: DR6 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| Safety Data Sheet |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the β-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.
Related Products
-
DR6 (mouse):Fc (human) (rec.) AG-40B-0062