AdipoGen Life Sciences

DR6 (mouse):Fc (human) (rec.)

As low as CHF 170.00

In stock

Only %1 left

AG-40B-0062-C05050 µgCHF 170.00

AG-40B-0062-30503 x 50 µgCHF 340.00

Specifications / Handling

More Information
Product Details
Synonyms	Death Receptor 6; Tumor Necrosis Factor Receptor Superfamily Member 21; TNFRSF21
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	Mouse DR6 (aa 42-348) is fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity	Mouse
MW	~80kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.1EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml after reconstitution.
Reconstitution	Reconstitute with 50μl sterile water.
Formulation	Lyophilized. Contains PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	UniProt link Q9EPU5: DR6 (mouse) AfCS Signalling Gateway link: DR6 (mouse)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the β-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

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