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AdipoGen Life Sciences
DR6 (mouse):Fc (human) (rec.)
170
CHF
CHF 170.00
In stock
AG-40B-0062-C05050 µgCHF 170.00
AG-40B-0062-30503 x 50 µgCHF 335.00
| Product Details | |
|---|---|
| Synonyms | Death Receptor 6; Tumor Necrosis Factor Receptor Superfamily Member 21; TNFRSF21 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Mouse DR6 (aa 42-348) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Mouse |
| MW | ~80kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
UniProt link Q9EPU5: DR6 (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the β-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.
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