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AdipoGen Life Sciences
Fc (human):RANKL, Soluble (mouse) (rec.)
As low as
265
CHF
CHF 265.00
In stock
Only %1 left
AG-40B-0059-C01010 µgCHF 265.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | TRANCE; ODF; OPGL; TNFSF11; CD254 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Mouse RANKL (aa 157-316) is fused at the N-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Mouse |
| Specificity |
Binds to mouse RANK. |
| Biological Activity |
Induces osteoclastogenesis of bone marrow-derived macrophages. |
| MW | ~55kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
UniProt link O35235: RANKL (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
Product-specific References
- Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland: M. Beleut, et al.; PNAS 107, 2989 (2010)
- RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma: J. Faget, et al.; J. Thor. Oncol. 13, 387 (2018)
- Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB: M. Lubrano di Ricco, et al.; Eur. J. Immunol. 50, 972 (2020)
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