AdipoGen Life Sciences

Angiopoietin-2 (mouse) (rec.)

CHF 230.00
In stock
AG-40B-0131-C01010 µgCHF 230.00
AG-40B-0131-30103 x 10 µgCHF 455.00
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Product Details
Synonyms Ang-2; Ang2; Angpt2; Agpt2
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence Mouse angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag.
Crossreactivity Human
Mouse
Specificity Binds to the human and mouse Tie-2 receptor.
MW ~70kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.05EU/μg purified protein (LAL test).
Concentration 0.1 mg /ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS with trehalose and Brij35.
Other Product Data UniProt link O35608: Angiopoietin-2 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

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