AdipoGen Life Sciences

Betatrophin (mouse) (rec.)

CHF 385.00
In stock
AG-40B-0144-C01010 µgCHF 385.00
AG-40B-0144-30103 x 10 µgCHF 770.00
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Product Details
Synonyms Angiopoietin-like Protein 8; ANGPTL8; Lipasin; Refeeding-induced Fat and Liver Protein; RIFL; Betatrophin
Product Type Protein
Properties
Source/Host CHO cells
Sequence

Mouse ANGPTL8 [betatrophin] (16-198) is fused at the N-terminus to a FLAG®-tag.

Crossreactivity Mouse
MW ~25kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.1EU/μg purified protein (LAL test).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS + 0.02% CHAPS.
Other Product Data

Uni-Prot link Q8R1L8: ANGPTL8 [Betatrophin] (mouse)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote β cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in β cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.

Product References
  1. Angiopoietin-like 8 Improves Insulin Resistance and Attenuates Adipose Tissue Inflammation in Diet-Induced Obese Mice: D. Luo, et al.; Exp. Clin. Endocrinol. Diabetes 128, 290 (2020)
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