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AdipoGen Life Sciences
Betatrophin (human):Fc (human) (rec.)
190
CHF
CHF 190.00
In stock
AG-40B-0145-C01010 µgCHF 190.00
AG-40B-0145-30103 x 10 µgCHF 385.00
| Product Details | |
|---|---|
| Synonyms | Angiopoietin-like Protein 8; ANGPTL8; Lipasin; Refeeding-induced Fat and Liver Protein; RIFL; Betatrophin |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Human ANGPTL8 [betatrophin] (22-198) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Human |
| Biological Activity |
Betatrophin (human):Fc (human) (rec.) binds to human Angiopoietin-3 in a ELISA binding assay with an EC50 of ~250-300 ng/ml. |
| MW | ~50kDa |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS + 0.02% CHAPS. |
| Protein Negative Control | |
| Other Product Data |
Uni-Prot link Q6UXH0: ANGPTL8 [Betatrophin] (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote β cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in β cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
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