IL-38 (aa 20-152) (human) (rec.) (His)

CHF 330.00
In stock
AG-40B-0169-C01010 µgCHF 330.00
AG-40B-0169-C100100 µgCHF 1'200.00
Replaces AG-40B-0129
More Information
Product Details
Synonyms Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
Product Type Protein
Properties
Source/Host E. coli
Sequence Human IL-38 (aa Leu20-Trp152) is fused at the C-terminus to a His-tag.
Crossreactivity Human
MW ~16kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 100µg size: 1 mg/ml
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS.
Other Product Data Uni-Prot link Q8WWZ1: Interleukin-38
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.

Product References
  1. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses: J. Mora, et al.; J. Mol. Cell Biol. 8, 426 (2016)
  2. Interleukin 38 protects against lethal sepsis: F. Xu, et al.; J. Infect. Dis. 218, 1175 (2018)
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