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AdipoGen Life Sciences
Fc (human):CD137L, Soluble (human) (rec.)
265
CHF
CHF 265.00
In stock
AG-40B-0173-C01010 µgCHF 265.00
AG-40B-0173-30103 x 10 µgCHF 530.00
Figure 1: Fc (human):CD137L, Soluble (human) (rec.) (AG-40B-0173) binds to human CD137. Method: CD137 (human):Fc was coated on an ELISA plate at 1μg/ml. After blocking and washing steps, indicated concentrations of Fc (human):CD137L, Soluble (human) (AG-40B-0173) was added. Following incubation for 1 h at RT, the binding was detected using an anti-human CD137L primary antibody (AG-20A-0031), following with an anti-IgG (mouse) (HRP) secondary antibody.
| Product Details | |
|---|---|
| Synonyms | 4-1BBL; TNFSF9 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The receptor-binding domain of human CD137L (aa 85-254) is fused at the N-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Human |
| Specificity |
Binds to human CD137 receptor. |
| MW | ~46kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
Uniprot link P41273: CD137L (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes and in T and B cell co-stimulation and modulation of the immune response.
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