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AdipoGen Life Sciences
Cystatin C (mouse) (rec.) (His)
As low as
440
CHF
CHF 440.00
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AG-40B-0300-C05050 µgCHF 440.00
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Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Cystatin 3; Cyst-C |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells. Produced using animal component-free medium. |
| Sequence |
The extracellular domain of mouse Cystatin C (aa 21-140) is fused at the N-terminus to a 6 x His tag. |
| Crossreactivity |
Human Mouse |
| MW | ~15 kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01 EU/μg purified protein (LAL test). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50μl endotoxin-free water. |
| Accession Number | P21460 |
| Formulation | Lyophilized. Contains PBS |
| Other Product Data |
NCBI reference P21460 : Cystatin C (mouse) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
Cystatin C (Cyst-C; Cystatin 3) is a member of the cystatin superfamily of cysteine protease inhibitors. Cystatin C is distributed in different organs and tissues and is associated with various immune responses to exogenous and endogenous antigens. The cystatin C gene is regulated by several factors during inflammation and infection. Cystatin C exerts its immunomodulatory functions by controlling the activity of cysteine proteases and other mechanisms.
For years, it has been observed that peripheral cancer inhibits amyloid pathology and rescues cognition in Alzheimer's disease. In a recent study, it was shown that Cystatin C secreted from peripheral tumor cells effectively reduces amyloid plaque burden and rescues cognition in mouse models of AD. Cystatin C, which acts as a ligand of triggering receptor expressed on myeloid cells 2 (TREM2), directly binds Aβ1-42 oligomers and activates TREM2 and enables microglia to phagocytose and degrade the pre-existing amyloid plaques.
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