PARP-2 [ARTD2] (mouse) (recombinant protein) (His) (high purity)

Specifications / Handling

More Information
Product Details
Synonyms	Poly(ADP-ribose) Polymerase; ADP-ribosyltransferase Diphtheria Toxin-like 2; NAD(+) ADP-ribosyltransferase 2
Product Type	Protein
Properties
Source/Host	Sf21 cells
Sequence	Mouse full-length PARP-2 [ARTD2] is fused to a His-tag.
Crossreactivity	Mouse
Biological Activity	≥600U/mg protein.
Purity	≥98% (SDS-PAGE)
Concentration	Lot dependent (0.2-1mg/ml)
Formulation	Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Other Product Data	UniProt ID O88554: PARP-2 (mouse)
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

PARP-2 [ARTD2] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Product References

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation: S.S. Haenni, et al.; Int. J. Biochem. Cell Biol. 40, 2274 (2008)

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PARP-2 [ARTD2] (mouse) (rec.) (His) (high purity)