PARP-3 [ARTD3] (human) (recombinant protein) (His) (high purity)

Specifications / Handling

More Information
Product Details
Synonyms	Poly(ADP-ribose) Polymerase 3; ADP-ribosyltransferase Diphtheria Toxin-like 3; NAD(+) ADP-ribosyltransferase 3
Product Type	Protein
Properties
Source/Host	Sf21 cells
Sequence	Human full-length PARP-3 [ARTD3] is fused to a HA-tag and a His-tag.
Crossreactivity	Human
Biological Activity	≥10U/mg protein (only monoADP-ribosyl transferase activity).
Purity	≥98% (SDS-PAGE)
Concentration	Lot dependent (0.2-1mg/ml)
Formulation	Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Other Product Data	UniProt ID Q9Y6F1: PARP-3 (human)
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

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PARP-3 [ARTD3] (human) (rec.) (His) (high purity)