IDO1 (human) Enzyme+Inhibitor Set

Specifications / Handling

More Information
Product Details
Synonyms	Indoleamine 2,3-dioxygenase; INDO; IDO
Product Type	Set
Properties
Application Set	Compound Screening
Crossreactivity	Human
Kit Contains	1 Set 1x50µg of IDO1 (human) (rec.) (His) (highly active) (Prod. No. AG-40B-0161) 1x100µg of MMG-0358 (Prod. No. AG-CR1-3630) Download our online Assay Procedure/Protocol.
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Documents
Manual	No
Assay Procedure	Download PDF
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

IDO1 is a heme-containing enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, that plays a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity.

The IDO1 (human) Enzyme+Inhibitor Set contains the active enzyme IDO1 (human) (rec.) (His) (AG-40B-0161), compound MMG-0358 (AG-CR1-3630), a very potent and specific inhibitor of IDO1, and protocols that can be used for IDO1 enzyme activity and IDO1 inhibition experiments.

Both components can be used in vitro:

• For cell culture to study the effect of hIDO1 in a cellular system.
• For screening assay to search for new inhibitors of hIDO1.

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