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AdipoGen Life Sciences
Mouse Plasma Cell Depletion Starter Set
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740
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CHF 740.00
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AG-44B-0020-KI011 SetCHF 740.00
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| Product Details | |
|---|---|
| Product Type | Set |
| Properties | |
| Application Set | Other |
| Specificity |
Both antibodies in the Mouse Plasma Cell Depletion Starter Set have been thoroughly validated in mice. Antibodies against APRIL (Centotto-1) and BAFF (Sandy-2) are injected in C57BL/6J at 2mg/kg (about 20-40µg/mouse) intraperitoneal (i.p.) once a week. For details see reference M. Eslami, et al.; PNAS 21, e2404309121 (2024).
|
| Crossreactivity | Mouse |
| Kit Contains |
NOTE: All antibodies are supplied at a concentration of 1mg/ml in PBS and levels of Endotoxin are <0.01EU/µg. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Manual |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The Mouse Plasma Cell Depletion Starter Set contains two blocking antibodies, APRIL (mouse), mAb (blocking) (Centotto-1) and BAFF (mouse), mAb (blocking) (Sandy-2), that are sufficient, when used together, to deplete the plasma cells in mouse and to phenocopy APRIL-ko and BAFF-ko mice. This starter set contains enough reagents to deplete plasma cells in 2-3 mice.
APRIL (A proliferation-inducing ligand, TNFSF13) / BAFF (B-cell-activating factor, TNFSF13B) axis is required and nonredundant to maintaining all IgA, and IgM antibody-secreting plasma cells and most of IgG antibody-secreting plasma cells in the bone marrow, spleen, gut and serum. APRIL and BAFF rely mainly on three ligand/receptor pairs: APRIL-BCMA, BAFF-TACI, and APRIL-TACI.
Product References
Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL and IL-6 in supporting antibody-producing cells in different tissues: M. Eslami, et al.: PNAS 21, e2404309121 (2024)
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