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AdipoGen Life Sciences
16-epi-Latrunculin B
220
CHF
CHF 220.00
In stock
AG-CN2-0034-C100100 µgCHF 220.00
| Product Details | |
|---|---|
| Synonyms | 16-epi-LatB |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H29NO5S |
| MW | 395.5 |
| CAS | 444911-05-1 |
| Source/Host Chemicals | Isolated from marine sponge Negombata magnifica. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Colorless viscous film. |
| Solubility | Soluble in DMSO or ethanol. |
| InChi Key | NSHPHXHGRHSMIK-WAXGXQFOSA-N |
| Smiles | [H][C@@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\C=C/CC\C(C)=C/C(=O)O2)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antiviral (against herpes simplex type 1 virus (HSV-1)) [1].
- Cytotoxic [1, 5].
- Depolymerizes actin filaments (F-actin) [2, 3, 4].
Product References
- Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B: T.R. Hoye, et al.; JACS 124, 7405 (2002) Abstract
- A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica: B. Vilozny, et al.; J. Nat. Prod. 67, 1055 (2004)
- Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties: A. Fürstner, et al.; PNAS 102, 8103 (2005)
- Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B: A. Fürstner, et al.; Chemistry 13, 115 (2007)
- Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges: T. Amagata, et al.; J. Med. Chem. 51, 7234 (2008)
- Differential binding of Latrunculins to G‑Actin: A molecular dynamics study: M. A. Helal, et al. J. Chem. Inf. Model. 53, 2369 (2013)
- Marine Drugs: A hidden wealth and a new epoch for cancer management: S. Eram, et al.; Curr. Drug. Metab. 19, (2018)
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