AdipoGen Life Sciences

16-epi-Latrunculin B

Name: 16- epi -Latrunculin B
Brand: AdipoGen Life Sciences
SKU: AG-CN2-0034
Price: 220.00 CHF
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AG-CN2-0034-C100100 µgCHF 220.00

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Specifications / Handling

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Product Details
Synonyms	16-epi-LatB
Product Type	Chemical
Properties
Formula	C₂₀H₂₉NO₅S
MW	395.5
CAS	444911-05-1
Source/Host Chemicals	Isolated from marine sponge Negombata magnifica.
Purity Chemicals	≥95% (HPLC)
Appearance	Colorless viscous film.
Solubility	Soluble in DMSO or ethanol.
InChi Key	NSHPHXHGRHSMIK-WAXGXQFOSA-N
Smiles	[H][C@@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\C=C/CC\C(C)=C/C(=O)O2)O1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Product-specific References

Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B: T.R. Hoye, et al.; JACS 124, 7405 (2002) Abstract
A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica: B. Vilozny, et al.; J. Nat. Prod. 67, 1055 (2004)
Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties: A. Fürstner, et al.; PNAS 102, 8103 (2005)
Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B: A. Fürstner, et al.; Chemistry 13, 115 (2007)
Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges: T. Amagata, et al.; J. Med. Chem. 51, 7234 (2008)
Differential binding of Latrunculins to G‑Actin: A molecular dynamics study: M. A. Helal, et al. J. Chem. Inf. Model. 53, 2369 (2013)
Marine Drugs: A hidden wealth and a new epoch for cancer management: S. Eram, et al.; Curr. Drug. Metab. 19, (2018)
Latrunculin U: a potent actin-disrupter from the Red Sea marine sponge Negombata magnifica: D.T.A. Youssef, et al.; Nat. Prod. Res. (ePub ahead of print) (2025)

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